Milk provides high quality protein essential for growth
Protein plays a role in building and maintaining body tissues, such as muscle and bone. Proteins are made of smaller building blocks called amino acids. There are 20 different types of amino acids, 9 of which are essential. Milk protein is considered high quality protein because it contains all 9 essential amino acids (EAAs) in relatively high quantities.
Milk and other dairy products plays a role in growth
The South East Asian Nutrition Surveys (SEANUTS) 1 study indicate dairy, as part of a healthy diet, plays an important role in children’s growth by providing essential amino acids (EAAs) with high bioavailability (Nguyen, 2018). Similarly, a systematic review of 12 studies conducted in Europe, USA, China, Northern Vietnam, Kenya, Indonesia and India found that dairy products, especially milk, stimulate height growth in children (De Beer, 2012). The authors noted that a daily milk supplement of approximately 245ml for a year resulted in additional linear growth of 0.4cm/year. Another study following American girls who consumed >3 servings of milk/day from the age of 10 years till adulthood, showed an additional adult height of around 5.6cm (Berkey CS, 2009).
The Dutch are currently the tallest people in the world. The population grew taller by around 20cm over the past 150 years. Research suggests the growth in height is partly attributed to the heavy consumption of dairy products (Schonbecket al., 2013 Pediatric Research).
According to in vivo studies, a possible explanation is that height growth is controlled by the mechanistic target of rapamycin complex C1 (mTORC1) (Laplante and Sabatini, 2012). When specific amino acids are deficient in the diet, mTORC1 senses the deficiency and represses protein and lipid synthesis and cellular growth (Laplante and Sabatini, 2012). Thus, a sufficient dietary intake of EAAs is necessary to meet the body’s requirements for normal height growth (Semba, 2016). Further human studies, particularly in children, is necessary to confirm this hypothesis.
Milk contains high quality protein
The classification of protein quality, known as the Protein Digestibility Corrected Amino Acid Score (PDCAAS) is determined on the basis of 3 characteristics (FAO, 1991):
- quantity of protein in a food;
- quantity of EAAs in the protein; and
- digestibility of the protein in the small intestine.
Milk protein scores well for these 3 items and has a PDCAAS of 1.0. Therefore, it is regarded as a high quality protein. Nevertheless, the PDCAAS method of determining protein quality has several limitations, and the FAO has advised that a new analysis method be used to measure protein quality.
The new method is known as the Digestible Indispensable Amino Acid Score or DIAAS (FAO, 2013). It takes into account the correction for digestibility differences between proteins through knowledge of the digestibility of each individual EAA and not on the digestibility of the entire protein. In the near future, the DIAAS method can more accurately determine which and how many amino acids from various protein sources are absorbed by the body.
For milk proteins, both PDCAAS and DIAAS values are well above 100%. Therefore, milk is considered a source of high quality protein as evidenced by its high digestibility factor and the surplus of EAA as compared to the reference EAA pattern (FAO 2013).
The digestibility of a protein is preferably measured at the end of the small intestine (terminal ileum). This is considered the best way to determine amino acid bioavailability in food protein for absorption and use in the body. This method also allows comparison of proteins taken from different food sources. Food may contain factors that influence the digestion process and may affect the availability of amino acids for absorption. An example of such anti-nutritional factors is the trypsin inhibitors found in vegetable protein sources (Schaafsma, 2012).
The liver can make non-essential or dispensable amino acids if dietary intake is insufficient, but it cannot produce the 9 EAAs. The 9 EAAs are phenylalanine, valine, threonine, tryptophan, methionine, leucine, isoleucine, lysine and histidine.
- Nguyen Bao KL et al. The consumption of dairy and its association with nutritional status in the South East Asian Nutrition Surveys (SEANUTS). Nutrients 2018;10(6). pii:E759.
- De Beer H. Dairy products and physical stature: a systematic review and meta-analysis of controlled trials. Econ Hum Biol 2012;10(3):299-309.
- Berkey CS et al. Dairy consumption and female height growth: prospective cohort study. Cancer Epidemiol Biomarkers Prev 2009;18:1881-7.
- Schonbeck Y et al. The world’s tallest nation has stopped growing taller: the height of Dutch children from 1955 to 2009. Pediatric Research 2013;73(3):371-7.
- Laplante M and Sabatini DM. mTOR signaling in growth control and disease. Cell 2012;149(2):274-93.
- Semba RD et al. Child stunting is associated with low circulating essential amino acids. EBioMedicine 2016;6:246-52.
- FAO/WHO. Protein Quality Evaluation. Organization FAO/WHO (eds). Rome, Italy: FAO/ WHO; 1991: 65.
- FAO Expert Consultation. Dietary protein quality evaluation in human nutrition. 2013. Available at: http://www.fao.org/ag/humannutrition/35978-02317b979a686a57aa4593304ffc17f06.pdf
- Schaafsma G. Advantages and limitations of the protein digestibility-corrected amino acid score (PDCAAS) as a method for evaluating protein quality in human diets. Br J Nutr 2012;108:S333-6.